<style type="text/css">
<!--
.con_div{
width:500px;
height:400px;
border:1px solid #666;
text-align:center;
display:table-cell;
vertical-align:middle;
background:red;
color:#EEE
}
/*FOR IE*/
.fixie{
width:0;
height:100%;
display:inline-block;
vertical-align:middle;
}
-->
</style>

<div class="con_div">
<span class="fixie"></span>
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</div>